An NFC South rivalry is on tap between the (0-2) and the (1-1) on Sunday at Bank of America Stadium in Charlotte. The Panthers  Brandon Manning Jersey enter Week 3 in search of their first win of the season after losing their first two games to the and by a combined five points. The Saints are coming off a hard-fought 20-10 NFC South lo s to and the .Kickoff is at 1 p.m. ET. New Orleans is favored by 2.5 points in the latest Panthers vs. Saints odds from Caesars Sportsbook, and the over/under is set at 41. Before making any Saints vs. Panthers picks, .The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated since its inception. The model enters Week 3 of the 2022 NFL season on an incredible 139-102 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick'em players four times during that  John Hayden Jersey span. Anyone who has followed it is way up.Now, the model has set its sights on and just locked in its picks and NFL predictions. . Here are several for Panthers vs. Saints:Panthers vs. Saints spread: Saints -2.5Panthers vs. Saints over/under: 41 pointsPanthers vs Glenn Hall Jersey . Saints picks:     Featured Game | Carolina Panthers vs. New Orleans Saints         Moneyline Spread Total  CAR   NO     The Panthers have historically had a great deal of succe s against quarterback . In 10 career starts against the Panthers, Winston has a 4-6 record, 16 interceptions, eight fumbles lost, and only nine touchdown pa ses. In his lone start against the Panthers in 2021, Winston had 111 yards pa sing, took four sacks and threw two interceptions.Ball security will be a point of emphasis for the Saints this week after the team turned the ball over five times in the second half of their Week 2 lo s to Tampa Bay. Defensively, New Orleans has played below expectations in 2022, but faces a favorable matchup against a struggling Carolina offense in Week 3.The Panthers are in desperate need of a win with Matt Rhule feeling the heat in Carolina. One area the Panthers need to be better in is in the turnover department. Through two games, Carolina has yet to record a takeaway, while they have turned the ball over three times -- all coming at the hands of quarterback .Mayfield  Graham Knott Jersey has been inconsistent in his first season with the Panthers, and will need to show signs of improvement, or  Clark Griswold Jersey the calls for will follow. The 2017 Heisman Trophy winner has complete 53.6% of his pa ses for 380 yards, two touchdowns and one interception. He also has two fumbles lost and a quarterback rating of 79.5.The model has simulated Panthers vs. Saints 10,000 times and the results are in. The model is leaning Over on the point total, and it also says one side of the spread hits more than 50% of the time. .So who wins Panthers vs. Saints? And which side of the spread hits more than 50% of the time? , and find out. Click here Click here Click here